FREQUENTLY ASKED QUESTIONS (FAQs)
ABOUT GEMTESA

When you're living with OAB, your bladder muscles may suddenly contract too frequently and too often, even when your bladder isn't full, creating an urgent feeling that you need to urinate.

As your bladder fills, nerve signals in your brain trigger your need to urinate. These signals tell your bladder to:

• •Relax the muscles of the pelvic floor and urethra
• •Contract (squeeze) the muscles in the bladder to release urine

However, when you're living with OAB, your bladder muscles may suddenly contract too frequently, even when your bladder isn't full, creating an urgent feeling that you need to urinate.

Your doctor may suggest:

• •Behavioral therapies, such as pelvic floor muscle training ("Kegels"); establishing routine timing of bathroom trips; or reducing fluid intake (especially at night); and avoiding drinks that are considered bladder irritants (for example, coffee and caffeine)
• •Medications used to treat overactive bladder. There are 2 main types of prescription treatments available for treating OAB symptoms:

• ◦Beta-3 agonists (β₃-agonists) work to lessen OAB symptoms by helping the bladder muscle relax so it can hold more urine
• ◦Antimuscarinics work to lessen OAB symptoms by helping to stop involuntary bladder contractions (the bladder squeezing itself without your control)

Remember, everyone is unique. No treatment is right for everyone, so you may need to try several treatments before finding one that works for you. It's important to continue working with your doctor to find the best ways to manage your OAB symptoms.

Try the 6-question OAB self-assessment tool before your next visit to the doctor to see if it's time to discuss treatments.

OAB may feel like a water valve opening unexpectedly, while BPH may feel like a partially clogged pipe that dribbles water. Both conditions can cause leakage, urgency, and frequency episodes.

Because OAB and BPH have similar symptoms, the diagnosis of OAB may be overlooked. It's important to ask your doctor to screen for both, as different medicines are used for each condition.

If you're already treating BPH and you are still bothered by OAB symptoms, the problem may not be your prostate — it may be a bladder issue. Ask your doctor to screen for both OAB and BPH, as different medicines are used for each condition.

In fact, GEMTESA is the first and only FDA-approved treatment for OAB symptoms like leakage episodes, urgency, and frequency that you can take with your BPH medication.

GEMTESA is a prescription medicine used to treat the following symptoms due to a condition called overactive bladder in adults, and in adult males taking medicine for benign prostatic hyperplasia (BPH):

• •Leakage episodes: Uncontrollable urine leaks
• •Urgency: "Gotta-go" now even when the bladder isn't full
• •Frequency: "Gotta-go" often — more than 8 times per day

It is not known if GEMTESA is safe and effective in children.

Your doctor may recommend GEMTESA based on its proven efficacy and safety profile observed in clinical trials.

GEMTESA is a type of medication called a "beta-3 agonist," which is designed to help relax your bladder muscle so it can hold more urine. This may help to reduce the urgent need to run to the bathroom and the number of leakage episodes you may experience.

Based on the findings in clinical trials, you may expect to see results from GEMTESA at 12 weeks (3 months). Individual results may vary.

The most common side effects of GEMTESA at 12 weeks in a clinical trial were headache, nasal congestion, sore throat or runny nose, diarrhea, nausea, and upper respiratory tract infection. These are not all the possible side effects of GEMTESA. For more information, ask your doctor or pharmacist.

GEMTESA is intended to be taken once daily. It comes in a single-dose pill that can be taken whole with a glass of water with or without food. In adults, GEMTESA tablets may be crushed, mixed with a tablespoon (~15 mL) of applesauce and taken immediately with a glass of water.

Savings and support may be available for eligible commercially insured patients. You may pay as little as $10 for each 30-day supply or as little as $0 for each 90-day supply* if you have commercial insurance (government plans like Medicare or Medicaid are not eligible) or GEMTESA is covered by your plan. You may pay as little as $95 for each 30-day supply if you have commercial insurance (government plans like Medicare or Medicaid are not eligible) or if GEMTESA is not covered by your plan. Visit the Savings Program and Support section to learn more.

*Restrictions and maximum saving limits apply. Coverage and out-of-pocket costs may vary. Offer not valid for patients participating in Medicare, Medicaid, or other government healthcare programs. See full Program Terms, Conditions, and Eligibility Criteria.